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Leber’s Congenital Amaurosis

A rare, inherited eye disorder that causing severe vision loss or blindness from birth or early infancy.

A blurry close up of a brown lab with a dark, blurry circle in the center.
A Close up of a brown lab.
A blurry close up of a brown lab with a dark, blurry circle in the center.

Normal vision vs. Leber’s Congenital Amaurosis

Overview


Leber's Congenital Amaurosis (LCA) is a rare, inherited eye disorder that primarily affects the retina, leading to severe vision loss or blindness from birth or early infancy. It is named after Theodor Leber, the German ophthalmologist who first described the condition in 1869. LCA is considered a form of congenital retinal dystrophy.



Key characteristics


Onset

Vision impairments are typically present at birth or become apparent within the first few months of life.  


Severity

LCA is associated with severe visual impairment, often resulting in legal blindness. The degree of vision loss can vary among affected individuals.  


Genetic Basis

LCA is primarily caused by mutations in various genes that are essential for the normal development and function of the retina. Several genes have been identified as contributing to different subtypes of LCA.  

Overview


Leber's Congenital Amaurosis (LCA) is a rare, inherited eye disorder that primarily affects the retina, leading to severe vision loss or blindness from birth or early infancy. It is named after Theodor Leber, the German ophthalmologist who first described the condition in 1869. LCA is considered a form of congenital retinal dystrophy.



Key characteristics


Onset

Vision impairments are typically present at birth or become apparent within the first few months of life.  


Severity

LCA is associated with severe visual impairment, often resulting in legal blindness. The degree of vision loss can vary among affected individuals.  


Genetic Basis

LCA is primarily caused by mutations in various genes that are essential for the normal development and function of the retina. Several genes have been identified as contributing to different subtypes of LCA.  

Overview


Leber's Congenital Amaurosis (LCA) is a rare, inherited eye disorder that primarily affects the retina, leading to severe vision loss or blindness from birth or early infancy. It is named after Theodor Leber, the German ophthalmologist who first described the condition in 1869. LCA is considered a form of congenital retinal dystrophy.



Key characteristics


Onset

Vision impairments are typically present at birth or become apparent within the first few months of life.  


Severity

LCA is associated with severe visual impairment, often resulting in legal blindness. The degree of vision loss can vary among affected individuals.  


Genetic Basis

LCA is primarily caused by mutations in various genes that are essential for the normal development and function of the retina. Several genes have been identified as contributing to different subtypes of LCA.  

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Leber Congenital Amaurosis

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