Macular degeneration

Ophthotech Fovista AMD Phase 3 trials results come up short

Ophthotech Corporation has announced that the pre-specified primary endpoint of mean change in visual acuity at 12 months was not achieved in its Phase 3 clinical trial investigating the superiority of Fovista® (pegpleranib) anti-PDGF therapy in combination with Eylea® (aflibercept) or Avastin® (bevacizumab) anti-VEGF therapy compared to Eylea or Avastin monotherapy for the treatment of

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Diabetic Retinopathy

Researchers identify new target for abnormal blood vessel growth in the eyes

A team led by Massachusetts Eye and Ear researchers has identified a novel therapeutic target for retinal neovascularization, or abnormal blood vessel growth in the retina, a hallmark of advanced diabetic eye disease. According to a report published online in Diabetes, the transcription factor RUNX1 was found in abnormal retinal blood vessels, and by inhibiting

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(c) Ophthotech

Ophthotech Announces Results from Pivotal Phase 3 Trials of Fovista ® in Wet AMD

Ophthotech Corporation has announced that the pre-specified primary endpoint of mean change in visual acuity at 12 months was not achieved in its two pivotal Phase 3 clinical trials investigating superiority of Fovista (pegpleranib) anti-PDGF therapy in combination with Lucentis (ranibizumab) anti-VEGF therapy compared to Lucentis monotherapy for the treatment of wet age-related macular degeneration

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Macular edema on OCT

Eylea outperforms Avastin for DME in patients with moderate vision loss

A two-year clinical trial that compared three drugs for diabetic macular edema (DME) found that visual improvement was greater for participants receiving the drug Eylea (aflibercept) than for those receiving Avastin (bevacizumab), but only among participants starting treatment with 20/50 or worse vision.  Gains after two years were about the same for Eylea and Lucentis

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PRP for diabetic retinopathy

Ranibizumab Found Effective Against Diabetic Retinopathy

In a randomized clinical trial conducted by DRCR.net of more than 300 participants, researchers have found that ranibizumab is an effective alternative to Panretinal photocoagulation (PRP) (laser therapy for treating diabetic retinopathy). Results also show that the drug therapy carries fewer side effects than the currently used laser treatment.