Spark Therapeutics has announced positive results from the Phase 3 pivotal trial of its lead gene therapy product candidate, SPK-RPE65, for the treatment of RPE65-mediated inherited retinal dystrophies (IRDs). These results represent the first successful randomized, controlled Phase 3 trial ever completed in gene therapy for a genetic disease.
Of patients presenting for hydroxychloroquine screening at a large multispecialty ophthalmic practice, almost half of the patients on hydroxychoroquine did not receive appropriate evaluation, indicating lack of adherence to guidelines. Spectral-domain optical coherence tomography (SD OCT) and 10-2 Humphrey visual field (HVF) were found to be the preferred screening modalities, with others being fundus autofluorescence (FAF)
READ MORE…
Results from a single-center, phase 1, randomized controlled clinical trial show that ocular gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration was found to be safe and well tolerated. The study enrolled patients with wet age-related macular degeneration at the Lions Eye Institute and the Sir Charles Gairdner Hospital in Nedlands, WA, Australia. Eligible
READ MORE…
In results from a new study that was presented at EURETINA, Aflibercept and ranibizumab were found to be safer than dexamethasone intravitreal implants for the treatment of central retinal vein occlusion.
A pioneering trial of a new treatment derived from stem cells for people with wet age-related macular degeneration (AMD) has commenced at Moorfields Eye Hospital following a successful operation on a patient.
Patients with active exudative age-related macular degeneration (AMD) are being treated with various treatment regimen, which may include intravitreal ranibizumab (lucentis), bevacizumab (avastin), aflibercept (eylea), etc. Some of these patients do not show benefit from these treatments, including repeat injections in many cases.
The Mediterranean diet may protect against diabetic retinopathy, according to a study published in Diabetes Care. Andrés Díaz-López, from Rovira i Virgili University in Reus, Spain, and colleagues conducted a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study. Patients with type 2 diabetes
READ MORE…
Tracking changes in the eye’s retina may help doctors provide more effective treatment for people with schizophrenia, according to researchers at Rutgers University and Mount Sinai’s New York Eye and Ear Infirmary. A link between vision problems and schizophrenia is well established, with as many as 62 percent of adult patients with schizophrenia experiencing visual
READ MORE…
A new study suggests that the occurrence of advanced forms of a diabetic eye disease remains low among children living with diabetes, regardless of how long they have had the disease or their ability to keep blood sugar levels controlled. Researchers are therefore recommending that most children with type 1 diabetes delay annual diabetic retinopathy screenings
READ MORE…
A multi-institutional team reports that vitamin D may play a significant role in eye health, specifically in the possible prevention of age-related macular degeneration, or AMD, among women who are more genetically prone to developing the sight-damaging disease. In a paper published in JAMA Ophthalmology online, the team found that women who are deficient in
READ MORE…